Computational Biology
Abstract artistic representation of alkaline hydrothermal vents with spiraling geological formations

The Drive to Life on Wet and Icy Worlds

This paper reformulates the submarine alkaline hydrothermal theory for the origin of life, positing that life emerged as a free energy converter driven by specific geological disequilibria - specifically redox and pH gradients across inorganic precipitate membranes - utilizing hydrogen, methane, and CO2 as primary feedstocks.

Computational Biology
A reconstruction of LUCA within its evolutionary and ecological context

The Nature of LUCA and Early Earth System

A comprehensive phylogenomic study dating LUCA to ~4.2 Ga and reconstructing it as a complex, anaerobic acetogen. The authors employ a novel cross-bracing molecular clock method and gene-tree-species-tree reconciliation to infer that LUCA possessed an early immune system and lived within a hydrogen-recycling ecosystem.