Computational Biology
Four types of protein folding energy landscapes from left to right - smooth funnel

Funnels, Pathways, and Energy Landscapes

Foundational paper establishing the energy landscape theory, folding funnels, and the principle of minimal frustration.

Computational Biology
Electron microscope image of Pyrolobus fumarii showing irregular coccoid cell structure

Three Domains of Life: Woese's Phylogenetic Revolution

Woese et al.'s landmark 1990 paper established the three-domain system based on ribosomal RNA phylogeny, revolutionizing …

Computational Biology
A reconstruction of LUCA within its evolutionary and ecological context

The Nature of LUCA and Early Earth System

Phylogenomic reconstruction of LUCA revealing a complex, 4.2 Ga old acetogen living in an established ecosystem.