DynamicFlow: Integrating Protein Dynamics into Drug Design
Flow matching model that co-generates ligands and flexible protein pockets, addressing rigid-receptor limitations in …
Bioinformatics
InvMSAFold: Fast & Diverse Inverse Folding
A fast, diverse inverse folding method combining deep learning with Potts models to capture full sequence landscapes.
Funnels, Pathways, and Energy Landscapes
Foundational paper establishing the energy landscape theory, folding funnels, and the principle of minimal frustration.
The Drive to Life on Wet and Icy Worlds
A reformulated theory for the origin of life focusing on alkaline hydrothermal vents as electrochemical reactors.
The Nature of LUCA and Early Earth System
Phylogenomic reconstruction of LUCA revealing a complex, 4.2 Ga old acetogen living in an established ecosystem.