Computational Biology
Four types of protein folding energy landscapes from left to right - smooth funnel

Funnels, Pathways, and Energy Landscapes

Foundational paper establishing the energy landscape theory, folding funnels, and the principle of minimal frustration.

Computational Biology
Abstract artistic representation of alkaline hydrothermal vents with spiraling geological formations

The Drive to Life on Wet and Icy Worlds

A reformulated theory for the origin of life focusing on alkaline hydrothermal vents as electrochemical reactors.

Computational Biology
A reconstruction of LUCA within its evolutionary and ecological context

The Nature of LUCA and Early Earth System

Phylogenomic reconstruction of LUCA revealing a complex, 4.2 Ga old acetogen living in an established ecosystem.