Funnels, Pathways, and Energy Landscapes
Foundational paper establishing the energy landscape theory, folding funnels, and the principle of minimal frustration.
Computational Biology
The Drive to Life on Wet and Icy Worlds
A reformulated theory for the origin of life focusing on alkaline hydrothermal vents as electrochemical reactors.
Three Domains of Life: Woese's Phylogenetic Revolution
Woese et al.'s landmark 1990 paper established the three-domain system based on ribosomal RNA phylogeny, revolutionizing …
How to Fold Graciously: The Levinthal Paradox
A perspective paper defining the Grand Challenge of protein folding: distinguishing kinetic pathways from thermodynamic …
The Nature of LUCA and Early Earth System
Phylogenomic reconstruction of LUCA revealing a complex, 4.2 Ga old acetogen living in an established ecosystem.
Generating Mini-Protein Trajectories with GROMACS
Systematic GROMACS workflows for simulating mini-proteins across multiple amino acids to generate diverse MD …
Mini-Protein Trajectory Generation
Automated GROMACS pipeline generating high-fidelity MD trajectories with atomic force extraction for Neural Network …